2) Wentz, Jefferson face a tough challenge
Carson Wentz will make his fifth start in place of McCarthy, 2-2 in the first four games. In two wins, Wentz has completed 72.2 percent of his passes, a 204.5 passer average and a 3-0 TD-INT split. In the two losses, Wentz has averaged 331.5 passing yards but has just a 63.6 completion percentage with one TD and two picks. Justin Jefferson and TJ Hockenson have been more productive with Wentz at QB, and Jordan Addison recorded a career-high nine catches for 128 yards against the Eagles last week. Jefferson should be busy and will be a tough cover for Tarheeb Still and the rest of LA’s secondary. The Chargers have allowed a 79.8 opponent rating in 2025, third-lowest in the NFL, but the Colts torched them for 38 points, with Daniel Jones registering a 113.4 passer rating on Sunday. Chargers safety Elijah Molden (thumb), who missed Sunday, was limited in Tuesday’s practice. Wentz has been at his best when the running game is humming, and Jordan Mason has generally performed well. He might even get help from Aaron Jones, who has returned to practice after being on injured reserve and was limited Tuesday.
3) Vikings, Chargers each have their share of offensive line issues
Wentz was not sure to start this game due to a left shoulder injury. He has been walked 14 times and hit 28 times in his four starts. The Vikings have had five different starting OLs in 2025; only the Panthers and Browns (six each) have had more this season. With OT Brian O’Neill (knee) not practicing Tuesday, the Vikings could have a shell group that closes again. They’ve also posted a 10.4 percent inside pressure percentage, according to Next Generation Stats, which is more than two percent higher than the next-worst team. The Vikings have allowed 11 sacks to inside rushers, also tops; third on that list is the Chargers with eight. The Chargers’ OL has fallen into disrepair since RT turned LT Joe Alt injured his ankle. Alt is expected to return Thursday, but he, Trey Pipkins and Jamaree Salyer were limited in Tuesday’s practice, making their status uncertain. With the way Brian Flores and Chargers defensive coordinator Jesse Minter operate, it could be a long night for the offensive lines — and the quarterbacks they’re tasked with protecting.