With a short turnaround on Thursday night, these precautions were not enough to improve Purdy’s health. His absence will call Jones back into action to replace him in a game that becomes increasingly difficult without Pearsall, Watkins and Jennings.
San Francisco has suffered unconventional injuries in 2025, which has had a significant impact on the offensive and protection units, with the headline for injury to Nick Bosa and now an irritating toe disease that affects Purdy. The 49ers have managed to start 3-1 but will be tested by their NFC West competitors in an ever-steep Thursday night challenge at Sofi Stadium.