The Bills are coming off a 12-5 campaign, a subpar season by their standards, and losing in the playoffs after making the playoffs as a wild-card team. That snapped a streak of five consecutive AFC East titles. Meanwhile, the Lions are also coming off a 9-8 campaign that saw them plummet from the top of the NFC North to the basement.
The Week 2 matchup could be ripe for some fireworks in the Bills’ new home. 2024 NFL MVP Josh Allen, 2025 league champion James Cook, and new receiver DJ Moore bring pop under rookie head coach Joe Brady. Jared Goff, Jahmyr Gibbs, Amon-Ra St. Brown, Jameson Williams and the Lions offense face a revamped Bills defense under new defensive coordinator Jim Leonard. Prime Video could be on a scoring spree to open its season.