Barkley suffered an ankle sprain in Sunday’s win over the Arizona Cardinals and is considered week to week, but head coach Brian Daboll kept the door open Tuesday for Barkley to play in San Francisco.
Instead, New York ruled out the RB, along with offensive linemen Ben Bredeson (concussion) and Andrew Thomas (hamstring) and linebacker Azeez Ojulari (hamstring), for Thursday Night Football.
Around The NFL will have more on Barkley’s status shortly.